Human immunodeficiency virus-1 tat induces hyperproliferation and dysregulation of renal glomerular epithelial cells.

Functional and Physical Consequence of Human Immunodefficiency Virus Transactivator TAT Interaction with Human Cell Cycle Regulator p53

Human immunodeficiency virus (HIV) transactivator Tat is a potent activator of both viral and cellu‌lar genes. Tat has also been implicated in the development of AIDS-related malignancy. Here, we show that Tat physically and functionally is able to sequester the cell cycle check point protein p53. This sequestration results in non-functional promoter activity of cyclin-dependent kinase/cyclin i...

Apoptosis Lymphoid, Epithelial, and Neuronal Cell Lines from Death by Human Immunodeficiency Virus Type 1 Tat Protein Protects

We report here that the tat gene product of human immunodeficiency virus type 1 was able to protect iymphoblastoid (Jurkat), epithelial (293) and neuronal (PC12) cell lines from apoptotic death induced by serum withdrawal. The rescue from apoptosis by Tat was reflected by an increased expression of Bci-2 protein in tat-positive Jurkat cells with respect to mock-transfected Jurkat cells after 3-...

Human immunodeficiency virus-1 induces loss of contact inhibition in podocytes.

Human immunodeficiency virus-associated nephropathy (HIVAN) affects up to 10% of HIV-positive black adults and children and is the leading cause of renal disease in infected individuals. The disease is characterized by proliferation of renal epithelial cells, both glomerular and tubular. Diseased kidneys are enlarged, and glomerular visceral epithelial cells (podocytes) express proliferation ma...

Observation of Inclusion Bodies in Renal Epithelial Cells of Experimelltally Infected Horses with African Horse-Sickness Virus

Human immunodeficiency virus type 1 Tat activity in human neuronal cells: uptake and trans-activation.

Neurological dysfunction in AIDS occurs in the absence of productive infection of neurons, and may involve modulation of neuronal cell function by viral or cellular products released from surrounding infected cells. The human immunodeficiency virus type 1 (HIV-1) trans-activator protein Tat may be one such factor, as it can act as a neurotoxin, induces marked morphological changes in neurons an...